F
IPR039764

RNA binding protein HABP4/SERBP1-like

InterPro entry
Short nameHABP4/SERBP1-like

Description

This entry includes proteins with a hyaluronan/mRNA-binding protein domain, including HABP4 hyaluronan-binding proteins, PAI-RBP1 (also known as SERBP1) and related sequences.

HABP4 binds hyaluronan (a glucosaminoglycan), but according to its intracellular localisation, it may not be relevant in vivo. It has binds RNA and regulates transcription and pre-mRNA splicing
[3, 4, 8, 9, 2]
.

SERBP1 is a ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilised in an inactive state and preserved from proteasomal degradation
[7]
. It acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilisation and storage in an inactive state and it may also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay
[1]
. It seems to play a role in PML-nuclear bodies formation
[6]
. The orthologue from S. pombe, oga-1, is a ribosome preservation factor that protects a small pool of nontranslating, vacant ribosomes in cells under nutrient starvation conditions. Under nutrient-limiting conditions, cells reduce ribosome biogenesis and degrade ribosomes via autophagy (ribophagy) or proteasomal degradation. It binds specifically G4 quadruplex (these are four-stranded right-handed helices, stabilised by guanine base quartets) and purine motif triplex (characterised by a third, antiparallel purine-rich DNA strand located within the major groove of a homopurine stretch of duplex DNA) nucleic acid structures. These structures may be present at telomeres or in rRNAs. Extends chronological lifespan when overexpressed
[5]
.

References

1.Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the Type-1 plasminogen activator inhibitor mRNA. Heaton JH, Dlakic WM, Dlakic M, Gelehrter TD. J. Biol. Chem. 276, 3341-7, (2001). View articlePMID: 11001948

2.Molecular characterization of a novel intracellular hyaluronan-binding protein. Huang L, Grammatikakis N, Yoneda M, Banerjee SD, Toole BP. J. Biol. Chem. 275, 29829-39, (2000). View articlePMID: 10887182

3.Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. Nery FC, Passos DO, Garcia VS, Kobarg J. J. Biol. Chem. 279, 11444-55, (2004). View articlePMID: 14699138

4.Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins. Nery FC, Rui E, Kuniyoshi TM, Kobarg J. Biochem. Biophys. Res. Commun. 341, 847-55, (2006). View articlePMID: 16455055

5.Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe. Ohtsuka H, Ogawa S, Kawamura H, Sakai E, Ichinose K, Murakami H, Aiba H. Mol Genet Genomics 288, 285-95, (2013). View articlePMID: 23640107

6.Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. Saito A, Souza EE, Costa FC, Meirelles GV, Goncalves KA, Santos MT, Bressan GC, McComb ME, Costello CE, Whelan SA, Kobarg J. J Proteome Res 16, 3147-3157, (2017). View articlePMID: 28695742

7.TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes. Shetty S, Hofstetter J, Battaglioni S, Ritz D, Hall MN. EMBO J 42, e112344, (2023). View articlePMID: 36691768

8.Functional association of human Ki-1/57 with pre-mRNA splicing events. Bressan GC, Quaresma AJ, Moraes EC, Manfiolli AO, Passos DO, Gomes MD, Kobarg J. FEBS J 276, 3770-83, (2009). View articlePMID: 19523114

9.Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery. Goncalves Kde A, Bressan GC, Saito A, Morello LG, Zanchin NI, Kobarg J. FEBS Lett. 585, 2556-60, (2011). View articlePMID: 21771594

GO terms

biological process

  • None

molecular function

cellular component

  • None
Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.