F
IPR040138

Mesoderm induction early response protein/metastasis-associated protein

InterPro entry
Short nameMIER/MTA

Description

MTA (metastasis-associated) proteins, including MTA1-3, are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex. Nevertheless, MTA1 and MTA2 have been shown to deacetylate non-histone proteins, such as p53. The expression of MTA proteins have been linked to human cancers
[2]
.

Mesoderm induction early response proteins (MIER1-3) are ELM2-SANT domain-containing proteins. MIER1 functions as a transcriptional repressor through its ability to recruit HDAC1/2 activity
[3]
. The function of MIER2 and MIER3 is not clear
[1]
.

References

1.Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, Paterno GD, Gillespie LL. PLoS ONE 12, e0169338, (2017). View articlePMID: 28046085

2.The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications. Toh Y, Nicolson GL. Clin. Exp. Metastasis 26, 215-27, (2009). View articlePMID: 19116762

3.Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. Ding Z, Gillespie LL, Paterno GD. Mol. Cell. Biol. 23, 250-8, (2003). View articlePMID: 12482978

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