D
IPR040622

Integrin beta, epidermal growth factor-like domain 1

InterPro entry
Short nameI-EGF_1

Description

This is the I-EGF domain 1 found in several integrin beta subunits. Structural analysis revealed the presence of four integrin epidermal growth factor-like (I-EGF) domains in integrin beta
[2]
. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains; this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end
[1]
.

References

1.Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops. Sen M, Springer TA. Proc. Natl. Acad. Sci. U.S.A. 113, 2940-5, (2016). View articlePMID: 26936951

2.Structural basis of integrin regulation and signaling. Luo BH, Carman CV, Springer TA. Annu. Rev. Immunol. 25, 619-47, (2007). View articlePMID: 17201681

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