D
IPR040647

SPIN-DOC-like, zinc-finger

InterPro entry
Short nameSPIN-DOC_Znf-C2H2

Description

This is a zinc finger domain C2H2 type which can be found in SPIN1 docking protein (SPIN-DOC). SPIN-DOC is a Spindlin1 (SPIN1) regulator that directly binds and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin
[1]
. Proteins containing this domain also include Epm2aip1, which is a glycogen synthase (GS)-associated protein. In the absence of Epm2aip1, the sensitivity of the liver to insulin, in which GS is a principal actor, is impaired
[2]
.

References

1.A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. Bae N, Gao M, Li X, Premkumar T, Sbardella G, Chen J, Bedford MT. J. Biol. Chem. 292, 20808-20817, (2017). View articlePMID: 29061846

2.Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance. Turnbull J, Tiberia E, Pereira S, Zhao X, Pencea N, Wheeler AL, Yu WQ, Ivovic A, Naranian T, Israelian N, Draginov A, Piliguian M, Frankland PW, Wang P, Ackerley CA, Giacca A, Minassian BA. J. Biol. Chem. 288, 34627-37, (2013). View articlePMID: 24142699

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