D
IPR040655

TIAM1, CC-Ex domain

InterPro entry
Short nameTIAM1_CC-Ex

Description

Tiam1 is a guanine exchange factor (GEF) for CDC42 and the Rho-family GTPase Rac1, which plays an important role in cell-matrix adhesion and in cell migration
[3, 1]
. Tiam1 is involved in multiple steps of tumorigenesis
[4]
.

This entry represents the CC and Ex subdomain found in the PH-CC-Ex globular domain of the Tiam1 and Tiam2 proteins (T-lymphoma invasion and metastasis). The CC subdomain forms an antiparallel coiled coil with two long α-helices, together with the C-terminal Ex subdomain they form a small globular domain comprising three α-helices. The CC subdomain of the Tiam2 PHCCEx domain follows the C-terminal alpha1 helix of the PH subdomain through a four-residue linker
[2]
.

References

1.Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, Macek B, Malliri A. Nat Commun 7, 10664, (2016). View articlePMID: 26887924

2.The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. Terawaki S, Kitano K, Mori T, Zhai Y, Higuchi Y, Itoh N, Watanabe T, Kaibuchi K, Hakoshima T. EMBO J. 29, 236-50, (2010). View articlePMID: 19893486

3.The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ. J. Mol. Biol. 398, 730-46, (2010). View articlePMID: 20361982

4.The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling. Boissier P, Huynh-Do U. Cell. Signal. 26, 483-91, (2014). View articlePMID: 24308970

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