IPR040700
ZNRF-3, ectodomain
InterPro entry
Short name | ZNRF-3_ecto |
Description
This domain is found in ZNRF-3 protein present in Danio rerio. ZNRF-3 is a transmembrane E3 ubiquitin ligase that antagonizes Wnt signalling, the signalling system used to mediate Rspo protein actions. ZNFR3 and RNF43, alongside the Rspo proteins, have emerged as a system with therapeutic potential for a number of pathological processes. This domain is known as the ectodomain
[1].
References
1.Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Zebisch M, Xu Y, Krastev C, MacDonald BT, Chen M, Gilbert RJ, He X, Jones EY. Nat Commun 4, 2787, (2013). View articlePMID: 24225776
Cross References
ENZYME
Contributing Member Database Entry
- Pfam:PF18212
Representative structure
4cdj: Structure of ZNRF3 ectodomain