D
IPR041058

Alpha-(1,3)-fucosyltransferase FucT, N-terminal

InterPro entry
Short nameFucT_N

Description

This is the N-terminal domain of the alpha chain found in Helicobacter pylori Fucosyltransferase protein which is involved in the production of Lewis x trisaccharide, a major component of lipopolysaccharide. The N-terminal domain contains the catalyst base, Glu-95 which is equivalent to the Asp-100 of other members of the glycosyltransferases-B family. The domain contains the pocket where LacNAc binds. The domain is composed of 2-10 heptad repeats and a conserved N-terminal α-β-α motif which has little sequence similarity to the conserved N-terminal motif in other glycosyltransferases
[1]
.

References

1.Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design. Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH. J. Biol. Chem. 282, 9973-82, (2007). View articlePMID: 17251184

Cross References

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