D
IPR041161

Tenascin, EGF-like domain

InterPro entry
Short nameEGF_Tenascin
domain relationships

Description

This entry represents the EGF-like domains found in Tenascin and Reelin proteins. A common feature of all EGF-like domains is that they are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). The EGF-like domain includes six cysteine residues which have been shown to be involved in disulfide bonds. The structure of several EGF-like domains has been solved. The fold consists of two-stranded β-sheet followed by a loop to a C-terminal short two-stranded sheet
[2]
.

Tenascins are extracellular matrix glycoproteins that act both as integrin ligands and as modifiers of fibronectin-integrin interactions to regulate cell adhesion, migration, proliferation and differentiation. Tenascins are usually composed of repeated epidermal growth factor (EGF)-like domains, fibronectin-type III (FNIII) domains and a C-terminal fibrinogen related domain (FReD)
[1]
.

Reelin is an extracellular matrix serine protease that regulates neuronal migration during embryonic development and acts as a modulator of synaptic transmission in the adult brain
[5]
. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons
[3, 4, 6]
. In the adult brain, reelin stabilizes the actin cytoskeleton by inducing cofilin phosphorylation. Decreased Reelin expression causes destabilization of neurons, which could have implications for brain disorders, such as epilepsy and schizophrenia
[7]
.

References

1.The evolution of tenascins and fibronectin. Adams JC, Chiquet-Ehrismann R, Tucker RP. Cell Adh Migr 9, 22-33, (2015). View articlePMID: 25482621

2.EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation? Engel J. FEBS Lett. 251, 1-7, (1989). View articlePMID: 2666164

3.Reelin is a ligand for lipoprotein receptors. D'Arcangelo G, Homayouni R, Keshvara L, Rice DS, Sheldon M, Curran T. Neuron 24, 471-9, (1999). View articlePMID: 10571240

4.Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, Hammer RE, Richardson JA, Herz J. Cell 97, 689-701, (1999). View articlePMID: 10380922

5.Emerging topics in Reelin function. Forster E, Bock HH, Herz J, Chai X, Frotscher M, Zhao S. Eur. J. Neurosci. 31, 1511-8, (2010). View articlePMID: 20525064

6.Role of Reelin in the development and maintenance of cortical lamination. Frotscher M, Chai X, Bock HH, Haas CA, Forster E, Zhao S. J Neural Transm (Vienna) 116, 1451-5, (2009). View articlePMID: 19396394

7.Role for Reelin in stabilizing cortical architecture. Frotscher M. Trends Neurosci. 33, 407-14, (2010). View articlePMID: 20598379

Cross References

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