IPR041559
DNA ligase, ATP-dependent, bacteriophage T7-type, C-terminal
InterPro entry
Short name | DNA_ligase_ATP-dep_T7_C |
Overlapping homologous superfamilies |
Description
This is the C-terminal domain found in ATP-Dependent DNA ligase from Bacteriophage T7. This domain has no ligase activity, however together with the N-terminal domain (domain 1) they bind to double-stranded DNA consistent with the idea that the DNA-binding site is between the domains in the intact protein. While the fold of domain 2 (this domain) is very similar to a number of other proteins that bind single-stranded DNA, this domain does not bind to single-stranded DNA but instead has a high affinity for double-stranded DNA
[1].
References
1.Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7. Subramanya HS, Doherty AJ, Ashford SR, Wigley DB. Cell 85, 607-15, (1996). View articlePMID: 8653795
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entry
- Pfam:PF17879