D
IPR041850

Nectin-1, second immunoglobulin domain

InterPro entry
Short nameNectin-1_Ig2
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the second immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, PRR1, PVRL1 or CD111).

Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. In addition nectins heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls), nectin-1 for example, has been shown to trans-interact with Necl-1
[1]
. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin
[2]
. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1)
[4]
. Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D
[3]
.

References

1.The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors. Sakisaka T, Ikeda W, Ogita H, Fujita N, Takai Y. Curr. Opin. Cell Biol. 19, 593-602, (2007). View articlePMID: 17942295

2.Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. Lim ST, Lim KC, Giuliano RE, Federoff HJ. J. Comp. Neurol. 507, 1228-44, (2008). View articlePMID: 18181141

3.Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus. Krummenacher C, Baribaud F, Ponce de Leon M, Baribaud I, Whitbeck JC, Xu R, Cohen GH, Eisenberg RJ. Virology 322, 286-99, (2004). View articlePMID: 15110526

4.Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia. Suzuki K, Hu D, Bustos T, Zlotogora J, Richieri-Costa A, Helms JA, Spritz RA. Nat. Genet. 25, 427-30, (2000). View articlePMID: 10932188

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.