IPR041908
CtsR, C-terminal domain superfamily
InterPro entry
Short name | CtsR_C_sf |
Overlapping entries |
Description
This superfamily correspond to the CtsR C-terminal dimerisation domain. CtsR is an important repressor that modulates the transcription of class III stress genes in Gram-positive bacteria, mainly from Firmicute species.
CtsR consists of an N-terminal domain, a DNA binding domain with a helix-turn-helix motif (HTH) and a C-terminal dimerisation domain organised in a four helix bundle, with an unknown function. CtsR has a role in forming a complex with DNA, binding to promoter regions of heat-shock genes. It is mainly involved in the regulatory network of the bacterial heat-shock response. The phosphorylation sites reside in the winged HTH domain
[1].
References
1.McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR. Fuhrmann J, Schmidt A, Spiess S, Lehner A, Turgay K, Mechtler K, Charpentier E, Clausen T. Science 324, 1323-7, (2009). View articlePMID: 19498169
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:1.10.1200.150