F
IPR043471

Zinc finger BED domain-containing protein 2/3

InterPro entry
Short nameZBED2/3

Description

This entry includes ZBED2 and ZBED3. The function of ZBED2 is not clear.

Zinc-finger BED domain-containing protein 3 (Zbed3) is a zinc finger protein that binds to axin and activates the Wnt/beta-catenin signalling. Interaction with axin is important for Zbed3 to inhibit beta-catenin phosphorylation, hence inhibiting beta-catenin degradation
[2]
. Zbed3 has been associated with insulin resistance and type 2 diabetes mellitus in humans
[3, 1]
.

References

1.Zinc-finger BED domain-containing 3 (Zbed3) is a novel secreted protein associated with insulin resistance in humans. Jia Y, Yuan L, Hu W, Luo Y, Suo L, Yang M, Chen S, Wang Y, Liu H, Yang G, Li L. J. Intern. Med. 275, 522-33, (2014). View articlePMID: 24283382

2.Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. Chen T, Li M, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L. J. Biol. Chem. 284, 6683-9, (2009). View articlePMID: 19141611

3.Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. Ohshige T, Iwata M, Omori S, Tanaka Y, Hirose H, Kaku K, Maegawa H, Watada H, Kashiwagi A, Kawamori R, Tobe K, Kadowaki T, Nakamura Y, Maeda S. PLoS ONE 6, e26911, (2011). View articlePMID: 22046406

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