F
IPR043556

StAR-related lipid transfer protein 5/6

InterPro entry
Short nameStARD5/6
Overlapping
homologous
superfamilies
 

Description

The steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain is a protein module of approximately 210 residues that binds lipids, including sterols. The START domain consists of an α/β helix-grip fold. Fifteen mammalian proteins, STARD1-STARD15, possess a START domain
[4]
. This entry includes StARD5 and StARD6.

StAR-related lipid transfer protein 5 (StARD5) contains a START domain that binds lipids, including sterols
[1]
. StARD5 primary binds bile acids, and may be involved in the transport of bile acids rather than cholesterol
[2]
.

StARD6 can bind cholesterol. It has cholesterol-transfer activity and StAR-like activity. STARD6 is restricted to the testes and is expressed during spermatogenesis in spermatids but not in steroidogenic cells
[3, 4]
.

References

1.The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. Soccio RE, Adams RM, Romanowski MJ, Sehayek E, Burley SK, Breslow JL. Proc. Natl. Acad. Sci. U.S.A. 99, 6943-8, (2002). View articlePMID: 12011452

2.StAR-related lipid transfer domain protein 5 binds primary bile acids. Letourneau D, Lorin A, Lefebvre A, Frappier V, Gaudreault F, Najmanovich R, Lavigne P, LeHoux JG. J. Lipid Res. 53, 2677-89, (2012). View articlePMID: 23018617

3.StAR-like activity and molten globule behavior of StARD6, a male germ-line protein. Bose HS, Whittal RM, Ran Y, Bose M, Baker BY, Miller WL. Biochemistry 47, 2277-88, (2008). PMID: 18211099

4.Give lipids a START: the StAR-related lipid transfer (START) domain in mammals. Alpy F, Tomasetto C. J. Cell. Sci. 118, 2791-801, (2005). View articlePMID: 15976441

GO terms

biological process

  • None

molecular function

cellular component

  • None
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