SprT-like domain-containing protein Spartan
Short name | Spartan |
Description
References
1.SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Halder S, Torrecilla I, Burkhalter MD, Popovic M, Fielden J, Vaz B, Oehler J, Pilger D, Lessel D, Wiseman K, Singh AN, Vendrell I, Fischer R, Philipp M, Ramadan K. Nat Commun 10, 3142, (2019). PMID: 31316063
2.Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan. Li F, Raczynska JE, Chen Z, Yu H. Cell Rep 26, 3336-3346.e4, (2019). PMID: 30893605
3.Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts. Larsen NB, Gao AO, Sparks JL, Gallina I, Wu RA, Mann M, Raschle M, Walter JC, Duxin JP. Mol Cell 73, 574-588.e7, (2019). PMID: 30595436
4.SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. Elife 5, (2016). PMID: 27852435
5.Spartan deficiency causes genomic instability and progeroid phenotypes. Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida YJ. Nat Commun 5, 5744, (2014). PMID: 25501849
6.Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Hogel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, Altmuller J, Nurnberg G, Nurnberg P, Bahlo M, Martin GM, Aalfs CM, Oshima J, Terzic J, Amor DJ, Dikic I, Ramadan K, Kubisch C. Nat Genet 46, 1239-44, (2014). PMID: 25261934
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entry
- PANTHER:PTHR21220