IPR044388
Non-structural protein 2, MERS-CoV-like
InterPro entry
Short name | NSP2_MERS-like |
Description
The functions of NSP2 remain unclear. SARS-CoV NSP2, rather than playing a role in viral replication, may be involved in altering the host cell environment; deletion of NSP2 from the SARS-CoV genome results in only a modest reduction in viral titers, and it has been shown to interact with two host proteins, prohibitin 1 (PHB1) and PHB2 which have been implicated in cellular functions, including cell-cycle progression, cell migration, cellular differentiation, apoptosis, and mitochondrial biogenesis
[1, 3]. MHV NSP2, also known as p65, different from SARS-CoV NSP2, may play an important role in the viral life cycle
[2].
This entry represents NSP2 from Middle East respiratory syndrome-related coronavirus (MERS-CoV) and betacoronaviruses in the merbecovirus subgenera (C lineage).
References
1.The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. J Virol 79, 13399-411, (2005). PMID: 16227261
Cross References
Contributing Member Database Entry
- CDD:cd21517