SMYD2, SET domain
Short name | SMYD2_SET |
Overlapping homologous superfamilies | |
domain relationships |
Description
References
1.SMYD proteins: key regulators in skeletal and cardiac muscle development and function. Du SJ, Tan X, Zhang J. Anat Rec (Hoboken) 297, 1650-62, (2014). PMID: 25125178
2.Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. Mitchell LH, Boriack-Sjodin PA, Smith S, Thomenius M, Rioux N, Munchhof M, Mills JE, Klaus C, Totman J, Riera TV, Raimondi A, Jacques SL, West K, Foley M, Waters NJ, Kuntz KW, Wigle TJ, Scott MP, Copeland RA, Smith JJ, Chesworth R. ACS Med Chem Lett 7, 134-8, (2016). PMID: 26985287
3.Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. Sweis RF, Wang Z, Algire M, Arrowsmith CH, Brown PJ, Chiang GG, Guo J, Jakob CG, Kennedy S, Li F, Maag D, Shaw B, Soni NB, Vedadi M, Pappano WN. ACS Med Chem Lett 6, 695-700, (2015). PMID: 26101576
4.Repression of p53 activity by Smyd2-mediated methylation. Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA, Kubicek S, Opravil S, Jenuwein T, Berger SL. Nature 444, 629-32, (2006). PMID: 17108971
5.Methylation of the retinoblastoma tumor suppressor by SMYD2. Saddic LA, West LE, Aslanian A, Yates JR 3rd, Rubin SM, Gozani O, Sage J. J Biol Chem 285, 37733-40, (2010). PMID: 20870719
6.Characterizing the Role of SMYD2 in Mammalian Embryogenesis-Future Directions. Jarrell DK, Hassell KN, Crans DC, Lanning S, Brown MA. Vet Sci 7, (2020). PMID: 32408548
7.Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Donlin LT, Andresen C, Just S, Rudensky E, Pappas CT, Kruger M, Jacobs EY, Unger A, Zieseniss A, Dobenecker MW, Voelkel T, Chait BT, Gregorio CC, Rottbauer W, Tarakhovsky A, Linke WA. Genes Dev 26, 114-9, (2012). PMID: 22241783
8.SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. Ohtomo-Oda R, Komatsu S, Mori T, Sekine S, Hirajima S, Yoshimoto S, Kanai Y, Otsuji E, Ikeda E, Tsuda H. Hum Pathol 49, 145-55, (2016). PMID: 26826421
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- CDD:cd19202