F
IPR045071

KH domain-containing BBP-like

InterPro entry
Short nameBBP-like
Overlapping
homologous
superfamilies
 

Description

This entry represents a group of KH domain-containing proteins that share protein sequence similarity with fungal BBP protein, such as KH domain-containing RNA-binding protein QKI and KHDR1-3 from human. QKI is a RNA-binding protein that plays a central role in myelination
[5]
and regulates pre-mRNA splicing, mRNA export and protein translation
[6]
.

BBP/SF1 family members include the branchpoint binding proteins (BBP) from yeast and their mammalian homologue, splicing factor 1 (SF1). They are KH domain containing proteins required for pre-spliceosome formation, which is the first step of pre-mRNA splicing
[1, 2]
. In budding yeasts, BBP binds the conserved RNA sequence UACUAAC, called the branchpoint motif, found near the 3' end of yeast introns
[3]
. Besides its function in pre-mRNA splicing, BBP is also involved in nuclear retention of pre-mRNA
[2]
. Mammalian SF1, also known as ZFM1, may act as transcription repressor
[4]
.

References

1.Pre-spliceosome formation in S.pombe requires a stable complex of SF1-U2AF(59)-U2AF(23). Huang T, Vilardell J, Query CC. EMBO J. 21, 5516-26, (2002). View articlePMID: 12374752

2.A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing. Rutz B, Seraphin B. EMBO J. 19, 1873-86, (2000). View articlePMID: 10775271

3.The branchpoint binding protein: in and out of the spliceosome cycle. Rymond BC. Adv. Exp. Med. Biol. 693, 123-41, (2010). PMID: 21189690

4.The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. Zhang D, Paley AJ, Childs G. J. Biol. Chem. 273, 18086-91, (1998). View articlePMID: 9660765

5.Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia. Aberg K, Saetre P, Jareborg N, Jazin E. Proc Natl Acad Sci U S A 103, 7482-7, (2006). PMID: 16641098

6.Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Teplova M, Hafner M, Teplov D, Essig K, Tuschl T, Patel DJ. Genes Dev. 27, 928-40, (2013). View articlePMID: 23630077

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