F
IPR046965

Cyclin A/B-like

InterPro entry
Short nameCyclin_A/B-like
family relationships

Description

This entry includes cyclin A, cyclin B and related sequences. Cyclin A/B are essential (and the most active) for the control of the cell cycle at the G2/M (mitosis) transition. They confer different substrate recognition properties on CDK2
[1, 2]
. DENR, an oncogene identified in several tumours, is phosphorylated by Cyclin A/CDK2 and Cyclin B/CDK1 at the onset of mitosis which promotes mitotic protein translation and faithful cell division
[2]
.

Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles
[4]
, and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.

Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus
[3]
.

References

1.Cyclin B and cyclin A confer different substrate recognition properties on CDK2. Brown NR, Lowe ED, Petri E, Skamnaki V, Antrobus R, Johnson LN. Cell Cycle 6, 1350-9, (2007). PMID: 17495531

2.Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division. Clemm von Hohenberg K, Muller S, Schleich S, Meister M, Bohlen J, Hofmann TG, Teleman AA. Nat Commun 13, 668, (2022). PMID: 35115540

3.Cyclin' on the viral path to destruction. Hardwick JM. Nat. Cell Biol. 2, E203-4, (2000). View articlePMID: 11056549

4.Cell cycle regulation and neural differentiation. Galderisi U, Jori FP, Giordano A. Oncogene 22, 5208-19, (2003). View articlePMID: 12910258

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