D
IPR047307

RNA-dependent RNA polymerase, hepevirus

InterPro entry
Short nameHepeviridae_RdRp
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the catalytic core domain or RNA-directed RNA polymerase (RdRp) domain of Non-structural polyprotein pORF1 of RNA viruses belonging to the family Hepeviridae. The family Hepeviridae includes enterically transmitted small non-enveloped (+)ssRNA viruses
[6, 7, 5, 1, 3]
. It includes the genera Piscihepevirus, whose members infect fish, and Orthohepevirus, whose members infect mammals and birds. Members of latter include hepatitis E virus
[7]
, which is responsible for self-limiting acute hepatitis in humans and several mammalian species; the infection may become chronic in immunocompromised individuals. Avian hepatitis E virus causes hepatitis-splenomegaly syndrome in chickens. Hepeviridae genomes (approximately 7.2 kb) have 5' methyl G caps and 3' poly (A) tails, and contain three ORFS. They have two mRNAs, a genome length and a subgenomic mRNA: the genome-length mRNA is translated to produce proteins required for RNA replication while the subgenomic mRNA is used to produce the capsid protein. Some of the capsid protein is glycosylated, which is an unusual finding for an unenveloped virus
[4]
.

This domain displays a right hand with three functional subdomains, called fingers, palm, and thumb and contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains
[2]
. All these motifs have been implicated in the fidelity on processes of correct incorporation and reorganization of nucleotides.

References

1.Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences. Koonin EV, Dolja VV. Crit. Rev. Biochem. Mol. Biol. 28, 375-430, (1993). View articlePMID: 8269709

2.Origin and Evolution of RNA-Dependent RNA Polymerase. de Farias ST, Dos Santos Junior AP, Rego TG, Jose MV. Front Genet 8, 125, (2017). PMID: 28979293

3.Origins and evolution of viruses of eukaryotes: The ultimate modularity. Koonin EV, Dolja VV, Krupovic M. Virology (Lond) 479-480, 2-25, (2015). PMID: 25771806

4.Origins and Evolution of the Global RNA Virome. Wolf YI, Kazlauskas D, Iranzo J, Lucia-Sanz A, Kuhn JH, Krupovic M, Dolja VV, Koonin EV. mBio 9, e02329-18, (2018). PMID: 30482837

5.Sogatella furcifera hepe-like virus: First member of a novel Hepeviridae clade identified in an insect. Wu N, Zhang P, Liu W, Wang X. Virus Res 250, 81-86, (2018). PMID: 29605729

6.ICTV Virus Taxonomy Profile: Hepeviridae. Purdy MA, Harrison TJ, Jameel S, Meng XJ, Okamoto H, Van der Poel WHM, Smith DB, Ictv Report Consortium . J Gen Virol 98, 2645-2646, (2017). PMID: 29022866

7.Ancient recombination events and the origins of hepatitis E virus. Kelly AG, Netzler NE, White PA. BMC Evol Biol 16, 210, (2016). PMID: 27733122

Cross References

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