RNA-binding protein FXR1, second Tudor-like Agenet domain
Short name | Tudor_Agenet_FXR1_rpt2 |
domain relationships |
Description
References
1.The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. Zhang Y, O'Connor JP, Siomi MC, Srinivasan S, Dutra A, Nussbaum RL, Dreyfuss G. EMBO J. 14, 5358-66, (1995). PMID: 7489725
2.New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes. Kim DY, Reynaud JM, Rasalouskaya A, Akhrymuk I, Mobley JA, Frolov I, Frolova EI. PLoS Pathog 12, e1005810, (2016). PMID: 27509095
3.RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Guo W, Zhang L, Christopher DM, Teng ZQ, Fausett SR, Liu C, George OL, Klingensmith J, Jin P, Zhao X. Neuron 70, 924-38, (2011). PMID: 21658585
4.Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J. PLoS ONE 5, e13559, (2010). View articlePMID: 21072162
5.Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo. Mientjes EJ, Willemsen R, Kirkpatrick LL, Nieuwenhuizen IM, Hoogeveen-Westerveld M, Verweij M, Reis S, Bardoni B, Hoogeveen AT, Oostra BA, Nelson DL. Hum. Mol. Genet. 13, 1291-302, (2004). View articlePMID: 15128702
6.Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain. Myrick LK, Hashimoto H, Cheng X, Warren ST. Hum. Mol. Genet. 24, 1733-40, (2015). View articlePMID: 25416280
7.Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy. Estan MC, Fernandez-Nunez E, Zaki MS, Esteban MI, Donkervoort S, Hawkins C, Caparros-Martin JA, Saade D, Hu Y, Bolduc V, Chao KR, Nevado J, Lamuedra A, Largo R, Herrero-Beaumont G, Regadera J, Hernandez-Chico C, Tizzano EF, Martinez-Glez V, Carvajal JJ, Zong R, Nelson DL, Otaify GA, Temtamy S, Aglan M, Issa M, Bonnemann CG, Lapunzina P, Yoon G, Ruiz-Perez VL. Nat Commun 10, 797, (2019). PMID: 30770808
Contributing Member Database Entry
- CDD:cd20475