D
IPR047478

Diacylglycerol kinase delta, first protein kinase C conserved region 1

InterPro entry
Short nameC1_DGKdelta_rpt1
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the first protein kinase C conserved region 1 (C1 domain) of DAG kinase delta and similar proteins from vertebrates. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn2-binding sites.

Diacylglycerol (DAG) kinase (
2.7.1.107
) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid.DGK-delta is a member of the diacylglycerol kinase family. DGK-delta is involved in the regulation of clathrin-dependent endocytosis
[2]
. It is a residential lipid kinase in the endoplasmic reticulum. It promotes lipogenesis and is involved in triglyceride biosynthesis
[7, 9, 4, 8, 6, 5]
. The SAM domain of DGK-delta proteins can form high molecular weight homooligomers through head-to-tail interactions as well as heterooligomers with the SAM domain of DGK-eta proteins. The oligomerisation plays a role in the regulation of the DGK-delta intracellular localisation: it inhibits the translocation of the protein to the plasma membrane from the cytoplasm
[1]
. The SAM domain also can bind Zn at multiple (not conserved) sites driving the formation of highly ordered large sheets of polymers, thus suggesting that Zn may play important role in the function of DCK-delta
[3]
. DAG kinase delta also contains two copies of the C1 domain.

References

1.Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1. Harada BT, Knight MJ, Imai S, Qiao F, Ramachander R, Sawaya MR, Gingery M, Sakane F, Bowie JU. Structure 16, 380-7, (2008). View articlePMID: 18334213

2.Regulation of clathrin-dependent endocytosis by diacylglycerol kinase delta: importance of kinase activity and binding to AP2alpha. Kawasaki T, Kobayashi T, Ueyama T, Shirai Y, Saito N. Biochem. J. 409, 471-9, (2008). View articlePMID: 17880279

3.Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ. Knight MJ, Joubert MK, Plotkowski ML, Kropat J, Gingery M, Sakane F, Merchant SS, Bowie JU. Biochemistry 49, 9667-76, (2010). View articlePMID: 20857926

4.Diacylglycerol kinase delta promotes lipogenesis. Shulga YV, Loukov D, Ivanova PT, Milne SB, Myers DS, Hatch GM, Umeh G, Jalan D, Fullerton MD, Steinberg GR, Topham MK, Brown HA, Epand RM. Biochemistry 52, 7766-76, (2013). PMID: 24090246

5.Diacylglycerol kinase δ controls down-regulation of cyclin D1 for C2C12 myogenic differentiation. Sakai H, Murakami C, Matsumoto KI, Urano T, Sakane F. Biochimie 151, 45-53, (2018). PMID: 29859210

6.Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Crotty T, Cai J, Sakane F, Taketomi A, Prescott SM, Topham MK. Proc Natl Acad Sci U S A 103, 15485-90, (2006). PMID: 17021016

7.Behavioral and pharmacological phenotypes of brain-specific diacylglycerol kinase δ-knockout mice. Usuki T, Takato T, Lu Q, Sakai H, Bando K, Kiyonari H, Sakane F. Brain Res 1648, 193-201, (2016). PMID: 27423518

8.Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics. Jiang LQ, de Castro Barbosa T, Massart J, Deshmukh AS, Lofgren L, Duque-Guimaraes DE, Ozilgen A, Osler ME, Chibalin AV, Zierath JR. Am J Physiol Endocrinol Metab 310, E51-60, (2016). PMID: 26530149

9.DGKδ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for the assembly of primary cilia. Ding J, Shao L, Yao Y, Tong X, Liu H, Yue S, Xie L, Cheng SY. Sci Rep 7, 5296, (2017). PMID: 28706295

Cross References

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