RNA-binding protein FXR1, second type I K homology domain
Short name | KH_I_FXR1_rpt2 |
Overlapping homologous superfamilies | |
domain relationships |
Description
References
1.The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. Zhang Y, O'Connor JP, Siomi MC, Srinivasan S, Dutra A, Nussbaum RL, Dreyfuss G. EMBO J. 14, 5358-66, (1995). PMID: 7489725
2.Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J. PLoS ONE 5, e13559, (2010). View articlePMID: 21072162
3.Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo. Mientjes EJ, Willemsen R, Kirkpatrick LL, Nieuwenhuizen IM, Hoogeveen-Westerveld M, Verweij M, Reis S, Bardoni B, Hoogeveen AT, Oostra BA, Nelson DL. Hum. Mol. Genet. 13, 1291-302, (2004). View articlePMID: 15128702
4.Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain. Myrick LK, Hashimoto H, Cheng X, Warren ST. Hum. Mol. Genet. 24, 1733-40, (2015). View articlePMID: 25416280
5.Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy. Estan MC, Fernandez-Nunez E, Zaki MS, Esteban MI, Donkervoort S, Hawkins C, Caparros-Martin JA, Saade D, Hu Y, Bolduc V, Chao KR, Nevado J, Lamuedra A, Largo R, Herrero-Beaumont G, Regadera J, Hernandez-Chico C, Tizzano EF, Martinez-Glez V, Carvajal JJ, Zong R, Nelson DL, Otaify GA, Temtamy S, Aglan M, Issa M, Bonnemann CG, Lapunzina P, Yoon G, Ruiz-Perez VL. Nat Commun 10, 797, (2019). PMID: 30770808
6.Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. Siomi MC, Zhang Y, Siomi H, Dreyfuss G. Mol Cell Biol 16, 3825-32, (1996). PMID: 8668200
7.Evidence that fragile X mental retardation protein is a negative regulator of translation. Laggerbauer B, Ostareck D, Keidel EM, Ostareck-Lederer A, Fischer U. Hum Mol Genet 10, 329-38, (2001). PMID: 11157796
8.New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes. Kim DY, Reynaud JM, Rasalouskaya A, Akhrymuk I, Mobley JA, Frolov I, Frolova EI. PLoS Pathog 12, e1005810, (2016). PMID: 27509095
Contributing Member Database Entry
- CDD:cd22507