D
IPR048008

Ecdysone-induced protein 78C-like, ligand binding domain

InterPro entry
Short nameNR_LBD_DmE78-like
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the ligand binding domain (LBD) of Drosophila E78 and its homologues.

Drosophila ecdysone-induced protein 78 (E78) is a transcription factor belonging to the nuclear receptor superfamily. E78 is a product of the ecdysone-inducible gene found in an early late puff locus at position 78C during the onset of Drosophila metamorphosis
[6, 1, 7]
. It is expressed throughout the germline during oogenesis, and is important for proper egg production and for the maternal control of early embryogenesis
[7]
. Two isoforms of E78, E78A and E78B, are expressed from two nested transcription units.

An E78 orthologue from the Platyhelminth Schistosoma mansoni (SmE78) has also been identified
[5]
. It is the first E78 orthologue known outside of the molting animals - the Ecdysozoa. SmE78 may be involved in transduction of an ecdysone signal in S. mansoni (
Q2TUU3
), consistent with its function in Drosophila. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, E78-like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD)
[2, 4, 3]
.

References

1.The Drosophila Eip78C gene is not vital but has a role in regulating chromosome puffs. Russell SR, Heimbeck G, Goddard CM, Carpenter AT, Ashburner M. Genetics 144, 159-70, (1996). View articlePMID: 8878682

2.The evolution of the nuclear receptor superfamily. Escriva H, Bertrand S, Laudet V. Essays Biochem. 40, 11-26, (2004). View articlePMID: 15242336

3.Principles for modulation of the nuclear receptor superfamily. Gronemeyer H, Gustafsson JA, Laudet V. Nat Rev Drug Discov 3, 950-64, (2004). View articlePMID: 15520817

4.Ligand binding and nuclear receptor evolution. Escriva H, Delaunay F, Laudet V. Bioessays 22, 717-27, (2000). PMID: 10918302

5.Schistosoma mansoni: SmE78, a nuclear receptor orthologue of Drosophila ecdysone-induced protein 78. Wu W, Tak EY, LoVerde PT. Exp Parasitol 119, 313-8, (2008). PMID: 18430421

6.The Drosophila 78C early late puff contains E78, an ecdysone-inducible gene that encodes a novel member of the nuclear hormone receptor superfamily. Stone BL, Thummel CS. Cell 75, 307-20, (1993). PMID: 8402914

7.Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila. Ables ET, Bois KE, Garcia CA, Drummond-Barbosa D. Dev Biol 400, 33-42, (2015). View articlePMID: 25624267

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