S
IPR048254

CDP-alcohol phosphatidyltransferase, conserved site

InterPro entry
Short nameCDP_ALCOHOL_P_TRANSF_CS

Description

This entry represents a conserved region found in a number of phosphatidyltransferases, which contains three aspartic acid residues.

A number of phosphatidyltransferases, which are all involved in phospholipid biosynthesis and that share the property of catalysing the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond share a conserved sequence region
[2, 3]
. These enzymes are proteins of 200 to 400 amino acid residues, including EPT1 from yeast, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferases from bacteria, CDP-diacylglycerol--serine O-phosphatidyltransferase from animals, among others. Also included in this entry is cardiolipin (CL) synthase (CMP-forming)/mitochondrial hydrolase fusion protein from S.pombe, a tandem fusion protein with a mitochondrial hydrolase. The CL synthase is essential for this organism
[1]
.

References

1.Schizosaccharomyces pombe cardiolipin synthase is part of a mitochondrial fusion protein regulated by intron retention. Vircikova V, Pokorna L, Tahotna D, Dzugasova V, Balazova M, Griac P. Biochim Biophys Acta Mol Cell Biol Lipids 1863, 1331-1344, (2018). View articlePMID: 29958934

2.Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae. Nikawa J, Kodaki T, Yamashita S. J. Biol. Chem. 262, 4876-81, (1987). View articlePMID: 3031032

3.sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products. Hjelmstad RH, Bell RM. J. Biol. Chem. 266, 5094-103, (1991). View articlePMID: 1848238

Cross References

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