D
IPR048409

DTX3L, KH-like domain

InterPro entry
Short nameDTX3L_KH-like

Description

DTX3L is a RING-domain E3 ubiquitin-protein ligase that regulates endosomal sorting of the G protein-coupled receptor CXCR4 from endosomes to lysosomes
[3]
. It also regulates subcellular localisation of its partner protein, B aggressive lymphoma (BAL), by a dynamic nucleocytoplasmic trafficking mechanism
[2, 1]
. This entry represents two copies of a domain found before the Znf domain (
IPR001841
) in DTX3L. According to structure predictions, it seems to be related to KH domains.

References

1.BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Juszczynski P, Kutok JL, Li C, Mitra J, Aguiar RC, Shipp MA. Mol. Cell. Biol. 26, 5348-59, (2006). View articlePMID: 16809771

2.The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA. J. Biol. Chem. 278, 21930-7, (2003). View articlePMID: 12670957

3.The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Holleman J, Marchese A. Mol. Biol. Cell 25, 1892-904, (2014). PMID: 24790097

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.