IPR048524
Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
InterPro entry
Short name | Lamp2-like_TM |
Description
This domain is found in Lysosome-associated membrane glycoprotein 2 from humans (Lamp2) and similar proteins from vertebrates. Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains (
IPR048528), a single transmembrane (TM) domain (this entry) and a short C-terminal cytosolic tail. It adopts a trimeric configuration, and the transmembrane domains of the three monomers form a three-helical bundle structure
[1].
References
Contributing Member Database Entry
- Pfam:PF21222