D
IPR048524

Lysosome-associated membrane glycoprotein 2-like, transmembrane domain

InterPro entry
Short nameLamp2-like_TM

Description

This domain is found in Lysosome-associated membrane glycoprotein 2 from humans (Lamp2) and similar proteins from vertebrates. Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains (
IPR048528
), a single transmembrane (TM) domain (this entry) and a short C-terminal cytosolic tail. It adopts a trimeric configuration, and the transmembrane domains of the three monomers form a three-helical bundle structure
[1]
.

References

1.Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP-2A) reveals key features for substrate specificity in chaperone-mediated autophagy. Rout AK, Strub MP, Piszczek G, Tjandra N. J Biol Chem 289, 35111-23, (2014). PMID: 25342746

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.