S
IPR048559

Disabled homolog 1/2, sulfatide-binding motif

InterPro entry
Short nameDAB1/2_SBM

Description

This region is found at the N-terminal end of human Disabled homolog 2 (DAB2) and similar sequences predominantly found in vertebrates. DAB2 is an adaptor protein involved in endocytosis, cell surface receptor turnover, and cell signalling. The membrane binding properties of this protein depend on its sulfatide-binding motifs (SBM, represented by this entry), which display a helical conformation
[1]
. This region is N-terminal to the PID domain (
IPR006020
).

References

1.Structure, sulfatide binding properties, and inhibition of platelet aggregation by a disabled-2 protein-derived peptide. Xiao S, Charonko JJ, Fu X, Salmanzadeh A, Davalos RV, Vlachos PP, Finkielstein CV, Capelluto DG. J Biol Chem 287, 37691-702, (2012). PMID: 22977233

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