IPR048790
Glycoprotein Gn, base, hantavirus
InterPro entry
Short name | Gn-B_hanta |
Description
The medium (M) genome segment of Hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins, Gn and Gc (also known as G1 and G2, respectively) as a polyprotein precursor
[4, 2, 1, 3]. Gn and Gc forms homotetramers (spikes) at the surface of the virion which attach the virion to host cell receptors including integrin beta3/ITGB3 and induce internalisation predominantly through clathrin-dependent endocytosis
[4, 2]. This entry represents the C-terminal region of the Gn ectodomain denoted as Gn base (Gn-B) which contributes the most to the intra-spike tetrameric contacts
[3].
References
1.Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118. Yoo DW, Kang CY. Nucleic Acids Res. 15, 6299-300, (1987). View articlePMID: 3114716
2.Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc. Guardado-Calvo P, Bignon EA, Stettner E, Jeffers SA, Perez-Vargas J, Pehau-Arnaudet G, Tortorici MA, Jestin JL, England P, Tischler ND, Rey FA. PLoS Pathog. 12, e1005813, (2016). PMID: 27783711
Contributing Member Database Entry
- Pfam:PF20679