D
IPR048790

Glycoprotein Gn, base, hantavirus

InterPro entry
Short nameGn-B_hanta

Description

The medium (M) genome segment of Hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins, Gn and Gc (also known as G1 and G2, respectively) as a polyprotein precursor
[4, 2, 1, 3]
. Gn and Gc forms homotetramers (spikes) at the surface of the virion which attach the virion to host cell receptors including integrin beta3/ITGB3 and induce internalisation predominantly through clathrin-dependent endocytosis
[4, 2]
. This entry represents the C-terminal region of the Gn ectodomain denoted as Gn base (Gn-B) which contributes the most to the intra-spike tetrameric contacts
[3]
.

References

1.Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118. Yoo DW, Kang CY. Nucleic Acids Res. 15, 6299-300, (1987). View articlePMID: 3114716

2.Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc. Guardado-Calvo P, Bignon EA, Stettner E, Jeffers SA, Perez-Vargas J, Pehau-Arnaudet G, Tortorici MA, Jestin JL, England P, Tischler ND, Rey FA. PLoS Pathog. 12, e1005813, (2016). PMID: 27783711

3.The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism. Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA, Guardado-Calvo P. Cell 183, 442-456.e16, (2020). PMID: 32937107

4.Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis. Jin M, Park J, Lee S, Park B, Shin J, Song KJ, Ahn TI, Hwang SY, Ahn BY, Ahn K. Virology 294, 60-9, (2002). PMID: 11886265

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