D
IPR048791

Glycoprotein Gc, C-terminal, bunyavirales

InterPro entry
Short nameGc_C_bunya

Description

The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins
[3, 2]
Gn and Gc (also known as G1 and G2, respectively) as a polyprotein precursor. Gn and Gc forms homotetramers at the surface of the virion, which attach the virion to host cell receptors including integrin beta3/ITGB3 and induce internalisation, predominantly through clathrin-dependent endocytosis
[4, 1]
. This protein has a typical class II fusion protein fold consisting of a central β-sandwich domain (termed domain I) made of eight β-strands arranged in two antiparallel β-sheets; domain II which has an elongated shape with two subdomains (a central, opened β-barrel proximal to domain I and a distal β-sandwich 'tip') and the C-terminal domain III, represented in this entry, which has a Ig-like fold
[3, 2]
. This domain is also found in similar proteins from bunyavirales.

References

1.Cellular entry of Hantaan virus A9 strain: specific interactions with beta3 integrins and a novel 70kDa protein. Mou DL, Wang YP, Huang CX, Li GY, Pan L, Yang WS, Bai XF. Biochem. Biophys. Res. Commun. 339, 611-7, (2006). PMID: 16310165

2.Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc. Guardado-Calvo P, Bignon EA, Stettner E, Jeffers SA, Perez-Vargas J, Pehau-Arnaudet G, Tortorici MA, Jestin JL, England P, Tischler ND, Rey FA. PLoS Pathog. 12, e1005813, (2016). PMID: 27783711

3.The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism. Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA, Guardado-Calvo P. Cell 183, 442-456.e16, (2020). PMID: 32937107

4.Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis. Jin M, Park J, Lee S, Park B, Shin J, Song KJ, Ahn TI, Hwang SY, Ahn BY, Ahn K. Virology 294, 60-9, (2002). PMID: 11886265

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.