IPR048791
Glycoprotein Gc, C-terminal, bunyavirales
InterPro entry
Short name | Gc_C_bunya |
Description
The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins
[3, 2] Gn and Gc (also known as G1 and G2, respectively) as a polyprotein precursor. Gn and Gc forms homotetramers at the surface of the virion, which attach the virion to host cell receptors including integrin beta3/ITGB3 and induce internalisation, predominantly through clathrin-dependent endocytosis
[4, 1]. This protein has a typical class II fusion protein fold consisting of a central β-sandwich domain (termed domain I) made of eight β-strands arranged in two antiparallel β-sheets; domain II which has an elongated shape with two subdomains (a central, opened β-barrel proximal to domain I and a distal β-sandwich 'tip') and the C-terminal domain III, represented in this entry, which has a Ig-like fold
[3, 2]. This domain is also found in similar proteins from bunyavirales.
References
1.Cellular entry of Hantaan virus A9 strain: specific interactions with beta3 integrins and a novel 70kDa protein. Mou DL, Wang YP, Huang CX, Li GY, Pan L, Yang WS, Bai XF. Biochem. Biophys. Res. Commun. 339, 611-7, (2006). PMID: 16310165
2.Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc. Guardado-Calvo P, Bignon EA, Stettner E, Jeffers SA, Perez-Vargas J, Pehau-Arnaudet G, Tortorici MA, Jestin JL, England P, Tischler ND, Rey FA. PLoS Pathog. 12, e1005813, (2016). PMID: 27783711
Contributing Member Database Entry
- Pfam:PF20682