IPR048939
Autophagy protein ATG5, UblA domain
InterPro entry
Short name | ATG5_UblA |
Overlapping homologous superfamilies |
Description
Autophagy protein ATG5 is involved in autophagic vesicle formation. It is conjugated with ATG12, acting as an E3-like ubiquitin enzyme required for lipidation of ATG8 family proteins and their association to the vesicle membranes. This is the N-terminal ubiquitin-like domain, termed UblA, from autophagy protein ATG5
[2, 1]. ATG5 comprises two ubiquitin-like domains (UblA and UblB) that flank a helix-rich domain (HBR). Both UblA and UblB comprise a five-stranded sheet and two-helices.
References
1.Structure of Atg5.Atg16, a complex essential for autophagy. Matsushita M, Suzuki NN, Obara K, Fujioka Y, Ohsumi Y, Inagaki F. J. Biol. Chem. 282, 6763-72, (2007). View articlePMID: 17192262
2.Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Otomo C, Metlagel Z, Takaesu G, Otomo T. Nat. Struct. Mol. Biol. 20, 59-66, (2013). View articlePMID: 23202584
Contributing Member Database Entry
- Pfam:PF20638