D
IPR048939

Autophagy protein ATG5, UblA domain

InterPro entry
Short nameATG5_UblA
Overlapping
homologous
superfamilies
 

Description

Autophagy protein ATG5 is involved in autophagic vesicle formation. It is conjugated with ATG12, acting as an E3-like ubiquitin enzyme required for lipidation of ATG8 family proteins and their association to the vesicle membranes. This is the N-terminal ubiquitin-like domain, termed UblA, from autophagy protein ATG5
[2, 1]
. ATG5 comprises two ubiquitin-like domains (UblA and UblB) that flank a helix-rich domain (HBR). Both UblA and UblB comprise a five-stranded sheet and two-helices.

References

1.Structure of Atg5.Atg16, a complex essential for autophagy. Matsushita M, Suzuki NN, Obara K, Fujioka Y, Ohsumi Y, Inagaki F. J. Biol. Chem. 282, 6763-72, (2007). View articlePMID: 17192262

2.Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Otomo C, Metlagel Z, Takaesu G, Otomo T. Nat. Struct. Mol. Biol. 20, 59-66, (2013). View articlePMID: 23202584

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.