D
IPR049391

Fatty acid synthase, pseudo-KR domain

InterPro entry
Short nameFAS_pseudo-KR

Description

Fatty acid synthase is a multifunctional enzyme that catalyses the de novo biosynthesis of long-chain saturated fatty acids, starting from acetyl-CoA and malonyl-CoA in the presence of NADPH
[1, 3, 2]
. This entry represents the pseudo-ketoreductase (pseudo-KR) domain which is catalytically inactive and supports the integrity of the active KR domain
[1, 2]
.

References

1.The crystal structure of a mammalian fatty acid synthase. Maier T, Leibundgut M, Ban N. Science 321, 1315-22, (2008). View articlePMID: 18772430

2.Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Martin MW, Lancia DR Jr, Li H, Schiller SER, Toms AV, Wang Z, Bair KW, Castro J, Fessler S, Gotur D, Hubbs SE, Kauffman GS, Kershaw M, Luke GP, McKinnon C, Yao L, Lu W, Millan DS. Bioorg Med Chem Lett 29, 1001-1006, (2019). PMID: 30803804

3.A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Hardwicke MA, Rendina AR, Williams SP, Moore ML, Wang L, Krueger JA, Plant RN, Totoritis RD, Zhang G, Briand J, Burkhart WA, Brown KK, Parrish CA. Nat Chem Biol 10, 774-9, (2014). View articlePMID: 25086508

Cross References

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