F
IPR049724

Trehalose monomycolate transport factor TtfA

InterPro entry
Short nameTreh_trans_TtfA

Description

This family represents the trehalose monomycolate transport factor A (TtfA) which is required for the transport of trehalose monomycolate across the inner membrane, potentially by forming a complex with the atypical lipid transporter MmpL3. Trehalose monomycolate is a component of the mycobacterial envelope. The core domain of TtfA shows strong structural similarity to class I type III secretion system (T3SS) chaperones. It is also required for growth and cell elongation
[1, 2]
.

References

1.Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria. Fay A, Czudnochowski N, Rock JM, Johnson JR, Krogan NJ, Rosenberg O, Glickman MS. mBio 10, e00850-19, (2019). PMID: 31239378

2.The crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA, reveals an atypical fold. Ung KL, Alsarraf HMAB, Kremer L, Blaise M. Proteins 88, 809-815, (2020). PMID: 31833106

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.