F
IPR050098

Tissue factor pathway inhibitor/Kunitz-type serine protease inhibitor-like
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InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameTFPI/VKTCI-like
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedReviewed and updated
This entry includes Tissue factor pathway inhibitor (TFPI) from animals and Kunitz-type serine protease inhibitors, also known as Venom chymotrypsin inhibitors (VKTCIs) which primarily function as inhibitors of serine proteases
[1, 2]
, with some members also exhibiting the ability to block voltage-gated potassium channels (Kv) such as Kunitz-type U15-theraphotoxin-Hhn1c from Chinese bird spider. These inhibitors are characterised by their Kunitz/BPTI domain, which is responsible for their protease inhibitory activity. The family includes toxins from various venomous organisms, such as snakes, scorpions, and sea anemones. Members of this family often have dual functions, inhibiting both serine proteases and ion channels, which contributes to their role in the defense mechanisms of the organisms that produce them. The inhibitory activities of these proteins are crucial for modulating processes like blood coagulation, inflammation, and neurotransmission, making them significant in both physiological and pathological contexts.

References

1.A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor. Droctove L, Ciolek J, Mendre C, Chorfa A, Huerta P, Carvalho C, Gouin C, Lancien M, Stanajic-Petrovic G, Braco L, Blanchet G, Upert G, De Pauw G, Barbe P, Keck M, Mourier G, Mouillac B, Denis S, Rodriguez de la Vega RC, Quinton L, Gilles N. Br J Pharmacol 179, 3470-3481, (2022). View articlePMID: 35122240

2.Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, Brinkmann V, Lorenz M, Bidzhekov K, Khandagale AB, Konrad I, Kennerknecht E, Reges K, Holdenrieder S, Braun S, Reinhardt C, Spannagl M, Preissner KT, Engelmann B. Nat Med 16, 887-96, (2010). View articlePMID: 20676107

GO terms

biological process

  • None

cellular component

  • None
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