IPR050131
Subtilisin-like serine protease AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Peptidase_S8_subtilisin-like AI |
Overlapping homologous superfamilies | |
family relationships |
Description
AI-generatedUnreviewed
The peptidase S8 family, also known as the subtilisin-like protease family, consists of serine proteases that exhibit a broad range of functions, primarily associated with the proteolytic cleavage of various substrates. Members of this family are involved in diverse biological processes, including cholesterol homeostasis, protein degradation, nutrient acquisition, pathogenicity, and regulation of developmental processes. They are characterized by their ability to cleave after hydrophobic or small residues, often requiring Arg or Lys at the P4 position. The family includes enzymes that activate transcription factors through regulated intramembrane proteolysis, mediate lysosome biogenesis, contribute to virulence in pathogenic organisms, and regulate plasma cholesterol levels. The proteolytic activity of these enzymes is typically regulated by propeptides, metal ions, or specific inhibitors.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR43806
Representative structure
8c4x: PAM Protease