F
IPR050131

Subtilisin-like serine protease
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short namePeptidase_S8_subtilisin-like
AI
Overlapping
homologous
superfamilies
 
family relationships

Description

AI-generatedUnreviewed
The peptidase S8 family, also known as the subtilisin-like protease family, consists of serine proteases that exhibit a broad range of functions, primarily associated with the proteolytic cleavage of various substrates. Members of this family are involved in diverse biological processes, including cholesterol homeostasis, protein degradation, nutrient acquisition, pathogenicity, and regulation of developmental processes. They are characterized by their ability to cleave after hydrophobic or small residues, often requiring Arg or Lys at the P4 position. The family includes enzymes that activate transcription factors through regulated intramembrane proteolysis, mediate lysosome biogenesis, contribute to virulence in pathogenic organisms, and regulate plasma cholesterol levels. The proteolytic activity of these enzymes is typically regulated by propeptides, metal ions, or specific inhibitors.

Cross References

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