IPR050147
Serine/Threonine Dehydratase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Ser/Thr_Dehydratase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The serine/threonine dehydratase family is characterized by enzymes that catalyze the dehydration of serine and threonine to their respective alpha-keto acids, often as part of amino acid catabolism or biosynthesis. Members of this family are involved in the anaerobic formation of alpha-ketobutyrate and ammonia from threonine through a two-step reaction involving dehydration and nonenzymatic hydrolysis of enamine/imine intermediates. Some members are regulated allosterically by compounds such as isoleucine, valine, and AMP, and may have additional regulatory domains influencing their activity. The family includes D-serine dehydratases, which specifically act on D-serine, and L-threonine dehydratases, which are involved in isoleucine biosynthesis. These enzymes play crucial roles in nitrogen metabolism and are found across various organisms, including bacteria, plants, and animals.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR48078