IPR050265
Iron/Manganese Superoxide Dismutase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Fe/Mn_Superoxide_Dismutase AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The iron/manganese superoxide dismutase family comprises enzymes that play a crucial role in cellular defense against oxidative stress. Members of this family catalyze the dismutation of the superoxide anion radical (O2-) into oxygen (O2) and hydrogen peroxide (H2O2), effectively mitigating the potential damage caused by these reactive oxygen species. These radicals are byproducts of normal cellular metabolism and can be harmful to biological systems if not regulated. The enzymes in this family are characterized by their metal cofactor, which can be either iron or manganese, and are found in various cellular compartments, including mitochondria. Some members are known to be resistant to inhibition by cyanide and azide, and their activity can be modulated by various factors, including the presence of hydrogen peroxide or metallothioneins.
Cross References
ENZYME
Contributing Member Database Entry
- PANTHER:PTHR11404
Representative structure
8vj4: X-ray Counterpart to the Neutron Structure of Peroxide-Soaked Trp161Phe MnSOD