F
IPR050265

Iron/Manganese Superoxide Dismutase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameFe/Mn_Superoxide_Dismutase
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The iron/manganese superoxide dismutase family comprises enzymes that play a crucial role in cellular defense against oxidative stress. Members of this family catalyze the dismutation of the superoxide anion radical (O2-) into oxygen (O2) and hydrogen peroxide (H2O2), effectively mitigating the potential damage caused by these reactive oxygen species. These radicals are byproducts of normal cellular metabolism and can be harmful to biological systems if not regulated. The enzymes in this family are characterized by their metal cofactor, which can be either iron or manganese, and are found in various cellular compartments, including mitochondria. Some members are known to be resistant to inhibition by cyanide and azide, and their activity can be modulated by various factors, including the presence of hydrogen peroxide or metallothioneins.

Cross References

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