F
IPR050325

Protein/nucleic acid deglycase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameProt/Nucl_acid_deglycase
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The protein family is involved in the cellular defense against glycation and oxidative stress. Members of the family function as protein and nucleotide deglycases, catalyzing the deglycation of Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. They repair methylglyoxal- and glyoxal-glycated proteins, releasing repaired proteins and lactate or glycolate. They deglycate cysteine, arginine, and lysine residues in proteins, reactivating them by reversing glycation. They also repair glycated guanine in nucleotides and nucleic acids, thus participating in a nucleotide repair system named guanine glycation repair (GG repair). Additionally, some members have been reported to possess chaperone, protease, and metal-binding activities, contributing to cell protection against oxidative stress and cell death. They may also be involved in mitochondrial function, autophagy of dysfunctional mitochondria, and inflammatory responses.

Cross References

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