IPR050394
Homeobox NK-like transcription regulators AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Homeobox_NK-like AI |
Description
AI-generatedUnreviewed
This family of proteins includes transcription factors that play critical roles in embryonic development and organogenesis. Members are involved in the specification and differentiation of various cell types, particularly within the central nervous system, heart, thyroid, lungs, and pancreas. They are characterized by their ability to bind DNA and regulate the expression of target genes, which influences processes such as neuron development, heart formation, and insulin production. Some proteins within this family act as transcriptional activators, while others function as repressors. They are also implicated in the maintenance of energy homeostasis and may have tumor suppressor functions.
Contributing Member Database Entry
- PANTHER:PTHR24340
Representative structure
3rkq: NKX2.5 Homeodomain dimer bound to ANF-242 DNA