F
IPR050437

Small ribosomal subunit protein bS1-like
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameRibos_protein_bS1-like
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedReviewed and updated
The bacterial ribosomal protein bS1 family is involved in the initiation of protein synthesis by binding mRNA and facilitating its recognition by the 30S ribosomal subunit
[3, 2, 1]
. Members of the family play a role in unwinding double-stranded RNA, preferentially binding to polypyrimidine tracts and transiently formed single-stranded RNA regions. Some family members are involved in trans-translation, a process that rescues stalled ribosomes by binding transfer-messenger RNA (tmRNA). Additionally, certain proteins within the family negatively autoregulate their own translation and may be involved in the translation of chloroplast-encoded proteins, heat stress response, and biosynthesis of thylakoid membrane proteins. The family includes proteins that are essential for the translation of most natural mRNAs, except for leaderless mRNA, and may act as RNA chaperones to unfold structured mRNA on the ribosome.

References

1.Escherichia coli ribosomal protein S1 unfolds structured mRNAs onto the ribosome for active translation initiation. Duval M, Korepanov A, Fuchsbauer O, Fechter P, Haller A, Fabbretti A, Choulier L, Micura R, Klaholz BP, Romby P, Springer M, Marzi S. PLoS Biol 11, e1001731, (2013). PMID: 24339747

2.Ribosomal protein S1 is not essential for the trans-translation machinery. Qi H, Shimizu Y, Ueda T. J Mol Biol 368, 845-52, (2007). View articlePMID: 17376482

3.Effects of ribosomal proteins S1, S2 and the DeaD/CsdA DEAD-box helicase on translation of leaderless and canonical mRNAs in Escherichia coli. Moll I, Grill S, Grundling A, Blasi U. Mol. Microbiol. 44, 1387-96, (2002). View articlePMID: 12068815

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