IPR050442
Peptidase S1 family, coagulation factors AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Peptidase_S1_coag_factors AI |
Description
AI-generatedUnreviewed
The peptidase S1 family, including vitamin K-dependent and snake venom subfamilies, consists of serine proteases involved in blood coagulation. Members of this family initiate various pathways of the coagulation cascade, convert prothrombin to thrombin, and regulate coagulation by inactivating factors. They participate in both intrinsic and extrinsic pathways, with some acting as zymogens in blood. Vitamin K-dependent proteins are crucial for the activation of these proteases, and calcium binding is a common feature that affects their conformation and interactions. The snake venom subfamily members attack prey hemostatic systems by mimicking mammalian coagulation factors, inducing blood clotting. This family also includes proteins that may control axon guidance in the CNS and influence cell surface receptor expression.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR24278
Representative structure
5voe: DesGla-XaS195A Bound to Aptamer 11F7t