F
IPR050474

Helicase Hel308/SKI2-like
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InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameHel308_SKI2-like
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Description

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The Helicase Hel308/SKI2 family includes ATP-dependent DNA and RNA helicases involved in various cellular processes such as DNA repair, ribosome quality control (RQC), and pre-mRNA splicing
[2, 3, 1]
. Members of the Hel308 subfamily primarily function in the 3'-5' unwinding of DNA at stalled replication forks, contributing to the repair mechanism. They exhibit DNA-dependent ATPase activity and may also process branched DNA structures like Holliday junctions. The SKI2 subfamily members are implicated in the RQC pathway, resolving stalled ribosomes during problematic translation, and play a role in pre-mRNA splicing as part of the spliceosomal complex. This family also includes helicases involved in homology-driven double-strand break (DSB) repair, such as unwinding DNA for microhomology-mediated end-joining (MMEJ) and other related DSB repair pathways.

References

1.Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation. Sitron CS, Park JH, Brandman O. RNA 23, 798-810, (2017). PMID: 28223409

2.ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8. Maeder C, Kutach AK, Guthrie C. Nat Struct Mol Biol 16, 42-8, (2009). View articlePMID: 19098916

3.A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308. Marini F, Wood RD. J Biol Chem 277, 8716-23, (2002). View articlePMID: 11751861

Cross References

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