F
IPR050568

Transcription/DNA replication regulator
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameTranscr_DNA_Rep_Reg
AI
Overlapping
homologous
superfamilies
 
Histone-fold (IPR009072)

Description

AI-generatedReviewed and updated
The protein family is involved in various aspects of transcriptional regulation and DNA replication. Members of the family function as components of larger complexes that interact with DNA and transcription factors to modulate gene expression
[1, 3, 2, 4]
. Some members, like Nuclear transcription factor Y subunit gamma, recognise specific DNA motifs, such as the CCAAT box, and are involved in the activation or repression of gene transcription. Others participate in chromosomal DNA replication, contributing to the synthesis of DNA strands and ensuring replication fidelity through proofreading exonuclease activity. The family also includes proteins that regulate the accessibility of chromatin by promoting nucleosome sliding, thus facilitating transcription and DNA repair. Overall, the family plays critical roles in maintaining cellular functions by regulating the expression of genes and ensuring the accurate replication of the genome.

References

1.The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. Kukimoto I, Elderkin S, Grimaldi M, Oelgeschlager T, Varga-Weisz PD. Mol. Cell 13, 265-77, (2004). View articlePMID: 14759371

2.Requirement of a corepressor for Dr1-mediated repression of transcription. Mermelstein F, Yeung K, Cao J, Inostroza JA, Erdjument-Bromage H, Eagelson K, Landsman D, Levitt P, Tempst P, Reinberg D. Genes Dev 10, 1033-48, (1996). View articlePMID: 8608938

3.Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex. He H, Li Y, Dong Q, Chang AY, Gao F, Chi Z, Su M, Zhang F, Ban H, Martienssen R, Chen YH, Li F. Proc Natl Acad Sci U S A 114, 12524-12529, (2017). View articlePMID: 29109278

4.The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, Houlder E, Kowalski CH, Raj S, Paul S, Cook P, Parker JE, Kelly S, Cramer RA, Latge JP, Moye-Rowley S, Bignell E, Bowyer P, Bromley MJ. Nat Commun 11, 427, (2020). PMID: 31969561

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.