IPR050633
Neuropilin/Multicopper Oxidase/Coagulation Factor AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Neuropilin_MCO_CoagFactor AI |
Description
AI-generatedUnreviewed
The protein family includes receptors involved in cardiovascular development, angiogenesis, neuronal circuit formation, and organogenesis. Members mediate chemorepulsant activity of semaphorins and bind to VEGF, initiating signaling pathways for motor neuron guidance and cell migration. Some family members are copper-binding glycoproteins with ferroxidase activity, playing roles in iron transport and antioxidant defense. Others are coagulation factors acting as critical cofactors in hemostasis. Additionally, the family includes proteins that contribute to phagocytic removal of apoptotic cells, mucosal healing, and VEGF-dependent neovascularization. They bind to phosphatidylserine-containing membranes and integrin receptors, influencing vascular morphogenesis and remodeling.
Contributing Member Database Entry
- PANTHER:PTHR46806
Representative structure
7o1n: Crystal Structure of Human Neuropilin-1 b1 Domain mutant - Y297A