F
IPR051095

Drosophila Developmental Transcription Regulators
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameDros_DevTransReg
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Description

AI-generatedUnreviewed
The protein family includes transcriptional regulators involved in various developmental processes in Drosophila melanogaster. Members act as transcriptional activators or repressors, influencing gene expression for segment specification, antenna development, sex determination, and courtship behavior. Some proteins within the family are essential for axon growth and guidance, repelling axons from the midline by regulating expression of midline repellents and their receptors. Others are involved in chromatin structure regulation, facilitating transcriptional activity by promoting open chromatin conformations, and are essential for processes such as zygotic genome activation and dosage compensation. Additionally, members participate in the formation of chromatin insulator complexes, which define transcriptional domains and protect against position effect variegation. The family also includes proteins that play roles in morphogenesis of muscles, sensory cells, and appendages, as well as in the differentiation of neurons and maintenance of stem cell identities.
Contributing Member Database Entry
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