IPR051320
Viral Replication and Maturation Polyprotein AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Viral_Replic_Matur_Polypro AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
The protein family is involved in the replication and maturation of viral genomes. Members encode polyproteins that are processed to yield proteases and reverse transcriptases. The protease activity cleaves the polyprotein in cis, while the reverse transcriptase exhibits DNA polymerase activity, copying DNA or RNA templates, and ribonuclease H activity, cleaving RNA-DNA heteroduplexes. The reverse transcription process encapsulates pregenomic RNA, synthesizing a relaxed circular DNA genome that migrates to the nucleus post-infection, converting into covalently closed circular DNA. Some members also integrate viral DNA into the host genome and are involved in virion maturation and capsid assembly.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR33064
Representative structure
3fsi: Crystal structure of a trypanocidal 4,4'-Bis(imidazolinylamino)diphenylamine bound to DNA