F
IPR051320

Viral Replication and Maturation Polyprotein
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameViral_Replic_Matur_Polypro
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The protein family is involved in the replication and maturation of viral genomes. Members encode polyproteins that are processed to yield proteases and reverse transcriptases. The protease activity cleaves the polyprotein in cis, while the reverse transcriptase exhibits DNA polymerase activity, copying DNA or RNA templates, and ribonuclease H activity, cleaving RNA-DNA heteroduplexes. The reverse transcription process encapsulates pregenomic RNA, synthesizing a relaxed circular DNA genome that migrates to the nucleus post-infection, converting into covalently closed circular DNA. Some members also integrate viral DNA into the host genome and are involved in virion maturation and capsid assembly.

Cross References

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