F
IPR051370

Peptidyl-prolyl cis-trans isomerase Pin1
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short namePPIase_Pin1
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedReviewed and updated
The Pin1 family of peptidyl-prolyl cis-trans isomerases (PPIases) is involved in the isomerization of specific phosphorylated Ser/Thr-Pro motifs, acting as molecular switches in various cellular processes
[cite:PUB00155191]
,
[cite:PUB00155192]
. Members of this family display a preference for acidic residues N-terminal to the proline bond to be isomerized
[1]
. They play roles in mitosis regulation, transcriptional control, protein folding, and cell transformation. Some family members are involved in the dephosphorylation and recycling of proteins post-mitogen activation, degradation of specific substrates in a phosphorylation-dependent manner, and regulation of DNA repair pathways. The WW domain present in many family members mediates protein-protein interactions. The activity of these enzymes can be regulated by inhibitors like juglone, buparvaquone, and others.

References

1.Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1. Yu L, Mohamed AJ, Vargas L, Berglof A, Finn G, Lu KP, Smith CI. J Biol Chem 281, 18201-7, (2006). View articlePMID: 16644721

2.Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. Steger M, Murina O, Huhn D, Ferretti LP, Walser R, Hanggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, Gerrits B, Del Sal G, Zerbe O, Sartori AA. Mol Cell 50, 333-43, (2013). View articlePMID: 23623683

3.The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation. Nechama M, Kwon J, Wei S, Kyi AT, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP. Nat Commun 9, 1603, (2018). View articlePMID: 29686383

Cross References

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