IPR051524
Betaine-homocysteine S-methyltransferase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | BHMT AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
This family of proteins is involved in the metabolic process of homocysteine regulation. Members of this family catalyze the transfer of a methyl group from betaine to homocysteine, resulting in the formation of dimethylglycine and methionine. This enzymatic activity is crucial for maintaining homocysteine levels within a narrow range, which is important for cardiovascular and neurological health. Additionally, the reaction mediated by these proteins is necessary for the irreversible oxidation of choline, a key step in the metabolism of this essential nutrient. Some family members utilize S-methylmethionine as a methyl donor instead of betaine, converting homocysteine directly to methionine. The activity of these enzymes can be modulated by various compounds, including dimethylglycine and methylthioacetate, which act as inhibitors.
Cross References
Contributing Member Database Entry
- PANTHER:PTHR46120
Representative structure
4m3p: Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine