IPR051670
TNF and chemokine receptor-like AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | TNF_chemokine_rcpt-like AI |
Description
AI-generatedUnreviewed
This family of proteins includes receptors that interact with tumor necrosis factor (TNF) and chemokines. They are involved in modulating the immune response by binding to these signaling molecules in the extracellular space, which inhibits the host's immune defense mechanisms. Some members mimic host TNF receptors and can bind TNF with high affinity, potentially preventing TNF from reaching its cellular targets and dampening its antiviral effects. The family also includes viral proteins that can bind host chemokines, thereby interfering with chemokine-mediated immune responses.
Contributing Member Database Entry
- PANTHER:PTHR47386
Representative structure
2uwi: Structure of CrmE, a poxvirus TNF receptor