IPR051682
Mitochondrial Persulfide Dioxygenase AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Mito_Persulfide_Diox AI |
Overlapping homologous superfamilies |
Description
AI-generatedUnreviewed
This family of proteins includes enzymes that are involved in hydrogen sulfide catabolism within the mitochondrial matrix. Members of this family function as sulfur dioxygenases, catalyzing the oxidation of cysteine persulfide residues that are generated from hydrogen sulfide by other enzymes. This oxidation process typically involves the transfer of the persulfide to a thiophilic acceptor such as glutathione. The activity of these proteins is crucial for preventing the accumulation of toxic levels of hydrogen sulfide, which can inhibit cytochrome c oxidase and disrupt metabolic homeostasis. Some members of this family have been implicated in additional cellular processes, including the regulation of apoptosis and cell adherence or biofilm development. The family belongs to the metallo-beta-lactamase superfamily and shares similarities with the Glyoxalase II family.
Cross References
ENZYME
Contributing Member Database Entry
- PANTHER:PTHR43084
Representative structure
2gcu: X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580