F
IPR051875

Calcineurin B homologous
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameCalcineurin_B_homologous
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The Calcineurin B homologous protein family is involved in a variety of cellular processes including cell pH regulation, vesicular trafficking, gene transcription, and signaling pathways. Members of this family function as cofactors that control plasma membrane-type Na(+)/H(+) exchange activity, thus influencing pH levels and cell survival under serum deprivation. They are involved in the stabilization and localization of the Na(+)/H(+) exchanger SLC9A1/NHE1 at the plasma membrane and can affect its pH sensitivity. Additionally, they play roles in the regulation of cell proliferation and tumor growth, and in the modulation of the calcineurin/NFAT signaling pathway, influencing transcription factor NFATC3 nuclear translocation and transcriptional activity. They also interact with microtubules and organelles of the endoplasmic reticulum and Golgi apparatus, and are implicated in the inhibition of ribosomal RNA transcription and kinase activity regulation.
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